Eric Wexler, M.D., Ph.D., Modern Brains PsychiatryEric Wexler, M.D., Ph.D.Diplomate, American Board of Psychiatry & Neurology

Neuropsychiatry

Conditions at the interface of neurology and psychiatry, where brain disease presents as changes in behavior, mood, and thought.

The Neuropsychiatry of NPH

Psychiatric symptoms in normal pressure hydrocephalus: apathy and depression prevalence, misdiagnosis in both directions, diagnostic workup, shunting outcomes, and psychotropic cautions.

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Neuroleptic Malignant Syndrome

A clinical review of NMS: recognition, risk factors, treatment, differential diagnosis, and rechallenge considerations.

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NMS Case Study

A de-identified composite teaching case with a day-by-day treatment timeline for neuroleptic malignant syndrome.

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Autoimmune Psychosis

Recognizing antibody-mediated psychosis such as anti-NMDA receptor encephalitis: red flags, consensus criteria, CSF workup, and immunotherapy.

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Neurocognitive Disorders

Interactive explorer of the spectrum of neurocognitive disorders, covering diagnosis, epidemiology, and clinical management of cognitive impairment.

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Wernicke-Korsakoff Syndrome

A clinical and epidemiological data dashboard for WKS: the thiamine deficiency continuum, biochemistry and blood-brain barrier transport, diagnostics, dosing and trials, and rehabilitation and policy.

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Psychiatric Genetics

Interactive psychiatric genetics and genomics explorer covering heritability, polygenic risk, pharmacogenomics, and genomic medicine in psychiatry.

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Psychosis and Regression in Down Syndrome

Separating Down Syndrome Regression Disorder from primary psychosis, catatonia, delirium, and reversible medical mimics in adolescents and young adults.

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Historical vs. Modern Sleep Patterns

The architecture of human slumber: segmented pre-industrial sleep, photoperiod biology, and CBT-I versus pharmacotherapy for insomnia.

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Computational Psychiatry

A guided set of tutorials on the computational models behind psychosis care: how the brain predicts, where prediction fails, and which treatments target each mechanism.

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Digital vs. Drug Addictions

How behavioral (digital) addictions and substance use disorders share reward circuitry and phenomenology, and where they diverge: toxicity, withdrawal, natural course, diagnosis, and treatment.

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Fluoroquinolone-Associated Disability (FQAD)

The FDA's multisystem fluoroquinolone syndrome: the tendinopathy, neuropathy, and CNS triad, neuropsychiatric effects, quantified risk, mechanisms, and management.

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Visual Snow Syndrome

A clinical review of VSS: consensus diagnostic criteria, mimics including migraine aura and HPPD, cortical hyperexcitability, prognosis, and treatment options.

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More topics in this section are in development and will be added soon.