Eric Wexler, M.D., Ph.D., Modern Brains PsychiatryEric Wexler, M.D., Ph.D.Diplomate, American Board of Psychiatry & Neurology

Special Topics

Computational Psychiatry Tutorials

A guided path through the computational models behind psychosis care: how the brain predicts, where prediction fails, and which treatments target each mechanism.

Foundations

Start with the core model

Computational Psychiatry: the founding framework

The Bayesian brain, precision weighting, and aberrant salience, built from the bottom up. Start here.

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Genesis of Psychosis

How prediction errors, priors, and belief updating give rise to delusion formation, with an interactive beads task.

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Mechanisms

How specific mechanisms fail

Jumping to Conclusions

The hasty data-gathering bias: how limited evidence sampling produces overconfident conclusions, and how it is measured.

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Restoring Agency in Schizophrenia

Corollary discharge, N1 suppression, and intentional binding: how self-authorship collapses and how it is rebuilt.

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Dysexecutive Syndrome (DES)

The supervisory attentional system explained, with a simulator showing how executive control breaks down.

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Computational Psychiatry of Delusions

Bayesian inference, predictive coding, and hierarchical psychopathology behind fixed false beliefs.

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Auditory Verbal Hallucinations

Why voices feel external: strong priors, weak sensory precision, and failures of self-monitoring.

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Formal Thought Disorder

Semantic network dynamics, speech graph metrics, and the computational signatures of disorganized thought.

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The Architecture of Referential Ideation

Ideas versus delusions of reference: aberrant precision, pseudo-social inference, and drift-diffusion dynamics.

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Loss of Agency in Schizophrenia

Efference copy, sensory attenuation, and how the feeling and judgment of agency come apart under active inference.

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Anhedonia & Apathy

Reinforcement learning, effort-based decision making, average reward rate, and vigor: deconstructing negative symptoms.

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Pareidolia & Pseudohallucinations

Hyper-precise priors, neuromodulatory gain, and reality monitoring: why ambiguous noise becomes faces and voices.

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Computational Psychiatry of Cognitive Biases

Jumping to conclusions, bias against disconfirmatory evidence, and confirmation bias modeled computationally.

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Applied

From theory to treatment

AI-Associated Psychosis

How generative AI acts on pre-existing vulnerability: aberrant salience, circular inference, hypermentalizing.

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Architecture of Cannabis-Induced Psychosis

How cannabinoid signaling perturbs precision weighting and dopaminergic salience along the path to psychosis.

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Metacognitive Training (MCT)

Turning computational insight into treatment: targeting overconfidence in errors and hasty causal attribution.

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Schizophrenia Simulations

Interactive simulations that make altered perception, salience, and thought disturbance experientially concrete.

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Amphetamine-Induced Psychosis

Dopamine sensitization, precision weighting, dose thresholds, and transition to schizophrenia.

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